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Philadelphia

From wilderness to foremost city of the colonies, and then to cosmopolitan capital of the Republic—this was Philadelphia’s first century

Yellow fever killed 4,000 in Philadelphia in 1793, and puzzled doctors ignored the real clue to blame “miasmata” in the air.

Late in the evening of August 21, 1793, Dr. Benjamin Rush, Philadelphia’s most prominent physician, sat down “much fatigued” to write to his wife to inform her that a “malignant lever” had broken out on the city’s water front.

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